What Is Spravato?

What Is Spravato?

Spravato is an innovative treatment for Major Depressive Disorder that has not responded to conventional therapies.

If you have not found significant relief from your depression symptoms after trying at least two different antidepressants, this could be the next option for you!



For the first four weeks, treatments are twice weekly, followed by four more weeks of weekly sessions. After eight weeks, you and Dr. David Wolff, M.D. will create an ongoing (maintenance) plan together.

A graph showing rapid and superior improvement in depressive symptoms at week 4 compared to placebo + oral ad for adults with trd
A graph showing secondary descriptive endpoints at week 4
A graph shows that madras scores were consistent through interim analysis at 4 years

What Are the Side Effects of Spravato?

Side effects can vary in intensity, and not everyone will experience the following effects:


  • Sedation: This is the most commonly reported side effect. Many patients find themselves needing a nap after receiving Spravato, but this sedation typically lessens over time.
  • Dissociation: Some individuals may feel a sense of disconnection from themselves, their thoughts, emotions, or their surroundings.
  • Blood Pressure Changes: A temporary rise in blood pressure may occur and can last for about four hours following a dose. We will monitor your blood pressure throughout your treatment.
  • Nausea: Some patients may experience nausea after administration of Spravato.
  • Anxiety: A short-term increase in anxiety symptoms can occur in some individuals after taking Spravato.

What to expect during a Spravato treatment?

Each Spravato treatment session begins with the patient self-administering the nasal spray in two to three doses, under medical supervision. Most Spravato patients commonly experience feelings drowsiness and/or a deep sense of relaxation. Patients often feel the effects of Spravato most intensely around 40 minutes after the first dose, and then they slowly subside. Patients stay for a duration of two hours of monitoring after Spravato treatments for their safety, and we ask that they arrange transportation home in advance. As you are monitored, our office is able to provide soothing music, mindfulness meditations, and aromatherapy. Patients are welcome to bring in their own entertainment for the two-hour monitoring period.

Share by: